Actress, comedienne, talk show host. Born March 21, 1962, in Commack, Long Island. Her father designed cameras for spy satellites and her mother was a homemaker. When Rosie was 10 years old, her mother died of pancreatic and liver cancer, leaving Rosie and her four brothers and sisters to fend for themselves emotionally. Rosie often sought the comfort of movies and television; finding idols and role models in Lucille Ball, Barbra Streisand, Carol Burnett, and Bette Midler. Rosie caught the acting bug when she imitated Gilda Radner’s character “Roseanne Rosannadanna” for a high school skit--inciting praise, then a conviction to pursue an acting career through comedy. By watching and imitating other comics, such as Jerry Seinfeld, O’Donnell eventually came up with her own material and honed her magnetic presence for the stage. After graduating from high school (O’Donnell was elected prom queen, homecoming queen, most school-spirited student, and class president), she embarked on a grand tour of the United States, appearing in 49 states over a five-year period. It was a difficult and enlightening time for O’Donnell, as she realized the unhealthy lifestyle and the sexist climate revolving around the comedy world. She told Robert Hoffler of Buzz, “Everybody was doing drugs and drinking, and I was just this little girl on the road, scared in her room.”

O’Donnell studied briefly at Dickinson College in Carlisle, Pennsylvania and Boston University and made five winning appearances on Star Search before moving to Los Angeles in 1984. She landed a part on the last season of NBC’s popular sitcom Gimme a Break before cable music video channel, VH-1, snatched her up as a veejay. When the station decided to stop using veejays, O’Donnell convinced them both to create a showcase for comedians, Stand-Up Spotlight, and keep her on as its host. Stand-Up Spotlight became the VH-1’s most popular show, and O’Donnell hosted for four years. In 1992, after appearing in several television specials, O’Donnell made a much-desired and anticipated move to film when Penny Marshall cast her as Madonna’s loveable sidekick in A League of Their Own. During filming, O’Donnell forged many connections and friendships which served to enhance her career, including an enduring relationship with co-star Madonna. Her role spurned a string of “best-friend” roles including “Becky,” Meg Ryan’s closest pal in 1993’s Sleepless in Seattle.