Though many mysteries remain surrounding the death of Silkwood, the public has gained much awareness about nuclear issues and has pressured the industry to become more responsible to health and safety concerns. As former Congresswoman Bella Abzug has commented, the issues stemming from the Silkwood case are "a matter of concern both in regard to public safety and the rights of individuals."

Silkwood's story was unveiled to a much greater audience in the 1983 film directed by Mike Nichols. Meryl Streep starred as Karen Silkwood with Kurt Russell and Cher in supporting roles. Silkwood garnered numerous Academy Award and Golden Globe nominations for acting, directing, and screenplay writing. Cher won a Golden Globe for Best Supporting Actress.